Mümtaz İşcan

Prof. Dr. MÜMTAZ İŞCAN

Faculty of Pharmacy

E-mail miscan@ciu.edu.tr
Telephone number +90 392 671 11 11
Extension 2661
Office ST244
Other information

U.N. Sustaınable Development Goals


Good health and well-being

CURRICULUM VITAE

Education
  • Ankara Toxicology (PhD, 1982)
  • Ankara Eczacılık (Undergraduate, 1975)
Thesis Supervision

Master Thesis Supervised

  • The investigation of the effects of nickel on mouse liver mixed function oxidase enzyme system
  • Interindividual variability of coumarin 7-hydroxylation in a Turkish population.
  • Investigation of lipid peroxidation levels in breast tumors
  • Investigation of the ethoxyresorufin O-deethylase enzyme activity in breast cancer
  • The effects of cadmium and nickel on rat testis xenobiotic metabolism
  • The clinical significance of interactions of warfarin, carbamazepin and amitriptilin interaction at metabolism level
  • The role of metabolic (GSTP1) polymorphism in lung cancer
  • The interactions of calcium channel blokers at metabolism level and the importance of CYP3A4
  • The role of metabolic (CYP1) polymorphism in drug resistance in lung cancer
  • The investigation of the GSTP1 gene polymorphism in some individuals of Turkish population
  • The investigation of the GST Omega 1 (A140D) gene polymorphism in some individuals of Turkish population
  • The role of metabolic (CYP1B1) polymorphism in drug resistance in lung cancer
  • The role of metabolic (CYP3A4) polymorphism in drug resistance in lung cancer

Doctorate Thesis Supervised

  • The investigation of the effects of cigarette smole on rat liver and lung xenobiotic metabolizing enzymes
  • The investigation of the antioxidant enzymes in breast carcinomas
  • The investigation of the role of metabolic polymorphism on the individual sensitivity to polycyclic aromatic hydrocarbons
  • The role of metabolic polymorphism in drug resistance in lung cancer
  • The role of metabolic (CYP2E1) polymorphism in drug resistance in lung cancer
  • The role of metabolic (mEH) polymorphism in drug resistance in lung cancer
  • Assessment of the serum periostin, tenascin-C, eopterin, YKL-40 and indolamin levels in asbest related malign mesotelioma
Projects
  • Assessment of the serum periostin, tenascin-C, eopterin, YKL-40 and indolamin levels in asbest related malign mesotelioma.
  • he role of metabolic (CYP3A4) polymorphism in drug resistance in lung cancer
  • The role of metabolic (CYP1B1) polymorphism in drug resistance in lung cancer
  • The role of metabolic (CYP2E1) polymorphism in drug resistance in lung cancer
  • The investigation of the GST Omega 1 (A140D) gene polymorphism in some individuals of Turkish population
  • The role of metabolic (CYP1) polymorphism in drug resistance in lung cancer
  • The role of metabolic (GSTP1) polymorphism in drug resistance in lung cancer
  • The investigation of the role of metabolic polymorphism on the individual sensitivity to polycyclic aromatic hydrocarbons
  • The investigation of the expression and localization of CYP1A1 and CYP1B1 which play role in development of breast cancer in normal and neoplastic breast tissue cells
  • The investigation of the combined effects of cadmium and nickel on rat lung and kidney cytochrome P450 enzyme system which play role in bioactivation of xenobiotics
  • The monitoring of the Van lake pollution by measuring fish cytochrome P-450 and glutathione S transferase enzyme activites as biological indicator.
  • The role of EROD activity in development of human breast cancer related with chemical carcinogens
  • The role of EROD (CYP1A1) enzyme activity on human breast cancer
  • The effects of benzimidazol compounds having retinodial acitivity on free radicals and lipid peroxidation
  • The investigation of the activites of antioxidant enzymes in breast carcinomas
  • The combined effects of cadmium and nickel on rat and guinea pig monoxygenases and glutathione conjugation enzymes
  • The investigation of the effects of nickel on mouse liver mixed function oxidase enzyme system
  • The investigation of the effects of cigarette smole on rat liver and lung xenobiotic metabolizing enzymes
Awards
  • ANKARA UNIVERSITY INCENTIVE AWARD IN HEALTH SCIENCES (1997)
  • SEDAT SİMAVI FOUNDATION AWARD IN HEALTH SCIENCES (1993)
  • Turkish Scientific and Technical Research Council (TUBITAK) Incentive Award in Medical Sciences (1991)
Research Areas
  • Molecular Toxicology
  • Risk Assessment of chemicals